Key microRNAs such as miR-143 and miR-145 are upregulated in rheumatoid arthritis fibroblast-like synoviocytes, targeting IGFBP5 and SEMA3A, resulting in elevated IL-6 production, NF-κB activation, and improved fibroblast-like synoviocyte survival and motility (79). This evidence concerns the gene IL6 and rheumatoid arthritis.