In a phase III, randomized, double-blind trial (Checkmate 066) of patients with untreated MM without v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations, nivolumab was found to have a much higher ORR and OS than dacarbazine, and the incidence of adverse events was lower (23). This evidence concerns the gene BRAF and Miyoshi myopathy.