demonstrated an increased frequency of MoDCs in Pag1-deficient mice and that HMGB1 may be involved in the progression of asthma by activating immature DCs, increasing their antigen-presenting capacity, and ultimately, promoting CD4+ T-cell differentiation to participate in the inflammatory response in T2-high-type asthma (56) (Figure 2). This evidence concerns the gene PAG1 and asthma.