The results indicated that there was no statistical difference in protein expression of SUZ12 between HCC cell lines and LX2 cell line, and the mRNA and protein expressions of PRR11, KIF11, RACGAP1, YY1, CREB1 were significantly higher than those of LX-2 cell line, especially HepG2 and HCC-LM3 cell lines (Figures 12D, E). Here, CREB1 is linked to hepatocellular carcinoma.