To better define the features of TME cell infiltration in HCC in the presence or absence of PVTT, multivariate Cox regression analyses were used to develop a prognostic model incorporating three of the nine core genes (PRR11, KIF11, and RACGAP1) with the following formula: risk score = KIF11*-0.194635376203241+PRR11*0.232461703663777+RACGAP1* 0.112717648336317. This evidence concerns the gene KIF11 and hepatocellular carcinoma.