RELA and intervertebral disk degenerative disorder: Research has shown that the Shen Sui Tong Zhi formula can target the NF-κB signaling pathway in CEP cells, modulate the expression of the key gene RELA and the phosphorylation of the key protein P65, reduce the expression of inflammatory factors and catenin proteins in the LSI surgery-induced CEP degeneration model, and upregulate the expression of antenin proteins, thus delaying IDD progression (Wang et al., 2024).