SOAT1 and neoplasm: Meanwhile, the upregulated DEGs in tumor areas of Glio-IDH-mut were enriched in five pathways, including MAPK signaling pathway, tight junction, NOD-like receptor signaling pathway, protein processing in endoplasmic reticulum, and JAK–STAT signaling pathway, while five pathways were enriched in tumor areas of Glio-IDH-wt such as relaxin signaling pathway, staphylococcus aureus infection, endocrine resistance, melanoma, and cholesterol metabolism (Figure 4B).