Meanwhile, the upregulated DEGs of Glio-IDH-mut were mainly enriched in “MAPK signaling pathway,” “tight junction,” “NOD-like receptor signaling pathway,” “protein processing in endoplasmic reticulum,” and “JAK–STAT signaling pathway.” Previous studies have proved that activation of the MAPK pathway (Pan et al., 2023), endoplasmic reticulum stress (Markouli et al., 2020), NOD-like receptor pathway (Chen et al., 2024), and JAK–STAT pathway (Zhang et al., 2019) accelerated glioma progression. The gene discussed is SOAT1; the disease is glioma.