KEGG enrichment analysis revealed that the upregulated DEGs in tumor areas of both Glio-IDH-wt and Glio-IDH-mut were mainly enriched in eight pathways, including PI3K/Akt signaling pathway, human papillomavirus infection, cytokine-cytokine receptor interaction, cytoskeleton in muscle cells, focal adhesion, human cytomegalovirus infection, regulation of actin cytoskeleton, and human T-cell leukemia virus 1 infection (Figure 4A). This evidence concerns the gene AKT1 and neoplasm.