Exiting studies have linked aberrant activation of the PI3K/Akt pathway (Barzegar Behrooz et al., 2022), human papillomavirus infection (Limam et al., 2020), cytokine-cytokine receptor interaction (Wang J. J. et al., 2021), and human T-cell leukemia virus 1 infection (Jin et al., 2006) with glioma development and progression. Here, AKT1 is linked to central nervous system cancer.