In this respect, (1) glibenclamide can interact with several other molecular targets including cystic fibrosis transmembrane conductance regulator Cl− channels (CFTR-Cl) [44], and peptide transporters 1 and 2 (PEPT1 and PEPT2) [45] and (2) reduction in KATP-mediated dilation, KATP currents, and KATP expresion in vascular smooth muscle cells were observed by Fan [46] in an experimental model of diet-induced obesity, ATP, impliying a reduction in the function of the KATP channel in obesity. Here, SLC15A1 is linked to obesity due to melanocortin 4 receptor deficiency.