As already reported by several studies, HFD causes hepatic steatosis [25], obesity-related dysbiosis [26] as well as cardiotoxicity [27], and an increase in hemodynamic (blood pressure and HR), zoometric (weight), and metabolic variables (glucose, insulin, leptin, and ghrelin) [15]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.