Patient No. 4 was confirmed to have a Noonan syndrome-like disorder with a pathogenic mutation in the SHOC2 gene, and patient No. 8 was confirmed to have mitochondrial disease (a possibly pathogenic variant m.3761C>A in the MT-ND1 gene causing mitochondrial complex I deficiency). The gene discussed is SHOC2; the disease is hyperinsulinemic hypoglycemia, familial, 4.