In a murine macrophage model of atherosclerosis, another histone deacetylase, HDAC6, was shown to promote nicotine-mediated inflammation and pyroptosis via deacetylation of p65, and activation of NF-kB and NLRP3 transcription (Xu et al., 2021). The gene discussed is NFKB1; the disease is atherosclerosis.