However, the absence of pleiotropy is supported by the non-significant MR-Egger intercept (p-value = 0.386), indicating that the observed associations are not likely due to pleiotropic effects where the genetic variants influence both the exposure (PSMA4 expression) and the outcome (NSCLC risk) in a biased manner (Supplementary Table S2). The gene discussed is PSMA4; the disease is non-small cell lung carcinoma.