Therefore, BPA can modulate transcription factors and ion channels, which generates damage such as mitochondrial stress, damage to the endoplasmic reticulum, and damage to the amyloid polypeptide of human islets.96 This causes the activation of NFκB in β cells located in the pancreas, generating unregulated glucagon secretion.96 There are conflicting studies regarding the incidence of asthma in children due to BPA, where three studies show a higher risk of asthma in childhood, and only one reported a low risk.97 The gene discussed is NFKB1; the disease is asthma.