constructed organoids resistant to platinum-based drugs from OC tumor cells derived from ascites, and by combining use of si-ZDHHC12 and cisplatin, they observed changes in the drug resistance of organoids while affecting the expression level of ZDHHC12, finding that the inhibition of ZDHHC12 can enhance the antitumor activity of cisplatin in OC (46). The gene discussed is ZDHHC12; the disease is neoplasm.