Similar to Wnt9a, sonic hedgehog was upregulated in the tubular epithelium of patients with proteinuric kidney diseases, such as IgA nephropathy, membranous nephropathy and focal segmental glomerulosclerosis (81), as it was in animal models of CKD induced by ischemia/reperfusion injury, adriamycin, renal mass ablation, or diabetes mellitus (81, 82). This evidence concerns the gene WNT9A and membranous glomerulonephritis.