These flavivirus infections have been shown to activate multiple signaling pathways that can either activate or inhibit apoptosis in virus-infected cells, such as endoplasmic reticulum (ER) stress and the AKT/PI3K pathway (Toru et al., 2017; Wang et al., 2017; Yang et al., 2020). This evidence concerns the gene AKT1 and Flavivirus Infections.