Moreover, HCC or HBV-HCC tumor tissues were with significantly higher expression level of PCGF3 than that in matched adjacent non-tumor tissues, HBsAg(+)/HBeAb(+)/HBcAb(+) HCC tumor tissues were with significantly higher expression level of PCGF3 than that in HBsAg(+)/HBeAg(+)/HBcAb(+) HCC tumor tissues, and males were more susceptible progression to HBV-related HCC compared to females (Figure 3C and Table 1). The gene discussed is PCGF3; the disease is hepatocellular carcinoma.