BGN and neoplasm: BGN encodes acetylheparin sulfate proteoglycan as a cell surface glycoprotein in the processes of cell adhesion, migration, and proliferation, and it also forms a stable adhesion structure through the interactions with other components in the basement membrane, thereby promoting the adhesion of tumor cells to the basement membrane and facilitating the migration and invasion of tumor cells in vivo (Haupt et al., 2009).