NOTCH1 and liver disorder: The latter leads to Notch‐dependent secretion of the neutrophil chemoattractant C‐X‐C motif chemokine ligand 1 (CXCL1), which promotes microthrombus formation and portal hypertension.[52] Endothelial Notch1 activation (or inducible EC‐specific expression of the Notch1 intracellular domain or NIC) in mice has been shown to lower the release of angiocrine signals, such as Wnt2, Wnt9b and HGF.[53] In addition, Notch1 activation enlarges the area of liver sinusoids and increases the number of apoptotic hepatocytes compared to controls.