Even though not the topic of this review, a lot work has been recently published on angiocrine signals in tumor cell growth and dissemination.[115, 116] For example, the suppression of angiocrine CC chemokine ligand 2 (CCL2) by adrenomedullin was shown to promote tumor growth.[117] Since CCL2 has principally been shown to be mechano‐responsive,[118] it would be interesting to analyze whether angiocrine secretion of CCL2 could be stimulated by an increased blood flow or increased blood/interstitial pressure in tumor tissue. This evidence concerns the gene CCL2 and neoplasm.