EDN1 and neoplasm: In general, since ECs actively shape the tumor microenvironment by releasing multiple angiocrine signals, for example, Ang‐2, basic Fibroblast Growth Factor (bFGF or FGF2), CCL2, EGF, endothelin 1, IL‐6, IL‐8, TGFβ, platelet‐derived growth factor‐β (PDGFβ), intracellular adhesion molecule 1 (ICAM‐1), vascular cell adhesion molecule (VCAM), angiomodulin (IGFBP7) and Jagged 1 (JAG1),[115, 120, 121, 122] further research on their potential mechanical regulation is warranted.