MAPT and Alzheimer disease: In August 2024, the Revised Criteria for Diagnosis and Staging of Alzheimer's disease: Alzheimer Association Workgroup was published.35The main aspect of these criteria is of a staging system for sporadic AD is that it takes into account the 6 clinical stages of the disease from asymptomatic (1) to severe dementia (6), and the 4 biological stages that are defined by amyloid PET and tau PET.