(In 34 cases, participants were only tau-PET-positive).37Even among those 120, who were positive for both amyloid and Tau PET, more than 40% remained cognitively normal after an average period of 3 and a half years of follow-up.37Therefore, they did not progress to dementia or even to mild cognitive impairment (MCI), demonstrating that there are more resilient individuals.37 The gene discussed is MAPT; the disease is Cognitive impairment.