The positive association between leptin levels and MADRS score at baseline after adjusting with age, sex, body mass index (BMI), Alcohol Use Disorders Identification Test score, and smoking was found (<i>p</i> = 0.011).<h4>Conclusion</h4>Our findings suggest that <i>LEPR</i> polymorphisms are associated with depression treatment response. This evidence concerns the gene LEP and alcohol abuse.