The shared proteins included several inflammatory factors previously reported to be elevated in DM and JDM patient sera: CXCL10 and CXCL9, cytokines that bind CXCR3 to promote immune cell activation and migration; GDF15, a cytokine involved in stress response pathways during cellular injury; MMP3, a matrix metalloproteinase associated with immune-mediated tissue injury; and vWF, a marker of endothelial damage [11, 28–36]. The gene discussed is GDF15; the disease is juvenile dermatomyositis.