BRCA1 and cancer: In study of the familial and non-familial 263 breast cancer patients (mean age 30-86) with the founder BRCA1 mutation carrier status identified between 1996-2009 distribution diagnosed cancer cases by (TNM) stage were: Familial cancer stage I -27.7%, II-53.2%, III-19.1%; Non familial cancer I-35.6%, II-45.4%, III-19.0% respectively.