Highly expressed suppressive genes included FAP, which has been shown to activate immune suppressive cells such as regulatory T-cells (Tregs) and myeloid-derived suppressor cells (MDSCs) [56, 57], INHBA, which fosters a switch in macrophage polarization towards a tumor-promoting state [58], VCAN, which has been shown to inhibit T-cell proliferation [59] and COL6A3, linked to the increased recruitment of macrophages [60]. Here, VCAN is linked to neoplasm.