Previous studies highlight that potassium channels are closely linked to the occurrence and progression of various diseases, such as arrhythmias [8], epilepsy [9], Alzheimer's disease [10], cerebral ischemia [11], and diabetes [12], etc. Intriguingly, an increasing number of recent studies indicate that changes in neural activity can contribute to the development of mental disorders, including depression [13–15]. The gene discussed is KCNA3; the disease is depressive disorder.