However, a recent report showed that refenestration is possible in metabolic dysfunction-associated steatohepatitis (MASH), termed before as non-alcoholic steatohepatitis (NASH) [81] indicating that LSECs still have the potential to induce fenestrations despite impaired expression of FVIII and VWF. Additionally, we observed that expression of Fcgr2b, encoding the signature receptor for endocytosis, was reduced in LSECs isolated from older but not from young Mcpip1 KO. Here, FCGR2B is linked to metabolic dysfunction-associated steatohepatitis.