Pde10a belongs to a family of phosphodiesterases and their inhibition has been suggested to modulate AD and other neurodegenerative disorders, potentially activating CREB (cAMP response element-binding)-dependent synaptic plasticity and memory formation (García-Osta et al, 2012; O’Connor et al, 2004; Puzzo et al, 2009), but these effects were related to expression of Pde10a in neurons, not astrocytes. This evidence concerns the gene CREB1 and Alzheimer disease.