Previous reports have demonstrated that gender can affect AD pathology, microglia response and APOE expression (Stephen et al, 2019; Thomas et al, 2016; Sala Frigerio et al, 2019), while the protective and disease causing effects of APOE2 and APOE4 are variable in different ethnic populations (Farrer et al, 1997; Naslavsky et al, 2022). This evidence concerns the gene APOE and Alzheimer disease.