Moreover, studying the effect of APOE isoforms in wild-type mice on neuronal development and synapse formation, will be of interest as APOE is known to influence synaptic density and to cause behavioural defects in AD mouse (Dumanis et al, 2009; Klein et al, 2010; Koffie et al, 2012). The gene discussed is APOE; the disease is Alzheimer disease.