We have been studying the deleted in liver cancer 1 (DLC1) tumor suppressor gene, which encodes a cytoplasmic focal adhesion protein, and recently reported that in lung cancer, cytoplasmic EZH2 methylates a specific DLC1 lysine residue, causing DLC1 ubiquitination and subsequent proteasome-dependent degradation4. The gene discussed is DLC1; the disease is lung cancer.