KRAS and lung adenocarcinoma: Perhaps most important, the complex was present in primary human lung adenocarcinomas with wild-type KRAS, KRAS-G12C mutant and KRAS-G12D mutant, with greater binding observed in the mutants (Fig. 5m,n), while complex formation was not detected between RanGAP1 and RAP1 (Extended Data Fig. 6p).