In colorectal cancer, EVs derived from adipose mesenchymal stem cells carry miR-15a, which targets lysine demethylase 4B (KDM4B) and inhibits PD-L1 expression by downregulating the binding of homeobox C4 (HOXC4) to the PD-L1 promoter180. This evidence concerns the gene HOXC4 and colorectal cancer.