Conversely, tumor cell-derived EVs carry the long noncoding RNA Kcnq1OT1, which competes with miR-30A-5p to bind to ubiquitin-specific protease 22 (USP22), increasing USP22 expression and severing the link between PD-L1 and ubiquitin chains53. The gene discussed is USP22; the disease is neoplasm.