TNFRSF8 and anaplastic large cell lymphoma: First-line treatment for the most common histological subtypes typically consists of CHOP-like chemotherapy (cyclophosphamide, doxorubicin, vincristine and prednisolone) with or without etoposide, and brentuximab vedotin for the CD30+ anaplastic large cell lymphoma (ALCL) subtype3.