The fact that the CC is mostly preserved from microtubule collapse in Ccp1−/− and Ccp5−/− mice is highly similar to what we previously observed for the deficiency of the bulge protein Lebercilin (LCA5), causing Leber Congenital Amaurosis in human (Faber et al, 2023). The gene discussed is AGBL5; the disease is Leber congenital amaurosis.