MYCN and neuroblastoma: However, sustained MYCN overexpression, as observed in MNA NB tumors, results in aberrant epitranscriptomic regulation and deregulation of critical genes such as HOXC8 and HOXC9. We need further understanding of how METTL3 recruitment in gene promoter could guide m6A methyltransferase complex to the specific locations in the RNA, such as the 3 ́end of the transcript (Barbieri et al, 2017).