In adjacent normal tissues, cells harbored dispersed CKAP4, but in tumor sites of great compaction CKAP4 was shown as speckles, and in metastatic cases (TM+), cancer cells exhibited more evident and denser CKAP4 speckles (Fig. 3j–l; Supplementary Fig. S5g, h), in line with the observation of CKAP4 speckles in the cell lines (Figs. 2c and 3g). The gene discussed is CKAP4; the disease is neoplasm.