ME2 and cancer: In addition, the succinylation level of ME2 K346 in CRC tissues was negatively correlated with the level of SIRT5 and correlated with patient prognosis.SIRT5-mediated desuccinylation of ME2 is a key signaling event for cancer cells to maintain mitochondrial respiration under glutamine-deficient conditions and to promote CRC progression, offering the possibility of targeting the SIRT5-ME2 axis for the treatment of CRC [34].