Transwell assays and cell scratch assays, on the other hand, showed that overexpression of PRMT1 promoted the ability of HCC cells to migrate and invade, whereas overexpression of PRMT1 combined with ME2 expression similarly reversed the ability of PRMT1 to promote migration and invasion (Fig. 3 D and E). The gene discussed is ME2; the disease is hepatocellular carcinoma.