Moreover, fluorescent IHC (F-IHC) analyses revealed a diminished intensity of staining for the stemness-related marker OCT4, alongside an intensified staining for markers indicative of differentiation (AFP, ACTA2 and CD57) in xenograft tumor tissues following SERPINB9 knockdown (Fig. 4h; Fig. S6f–j). The gene discussed is ACTA2; the disease is neoplasm.