IL1B and Alzheimer disease: In the serum samples, there was a strong positive correlation of our ASC speck marker with IL-1β levels in both AD and HC serum samples (R = 0.73, p = 0.021 (*) in HC serum, R = 0.28, p = 0.23 in AD serum, R = 0.43, p = 0.019 (*) when combined AD and HC serum samples together) (See the Supplementary Fig. 7A, B).