For comparison with our ASC speck measurements, we also measured the concentration of a panel of cytokines (IL-1β, IFN-γ, IL-2, IL-4, IL-6, IL-10, IL-12p70, IL-17A, TNF-α) and C-reactive protein (CRP) levels in our cohort of 20 AD with moderate dementia and 10 HC serum samples (see the Methods section for details). This evidence concerns the gene TNF and Alzheimer disease.