MAPT and Alzheimer disease: By combining the quantity of ASC specks with measures of Aβ, α-syn and p-tau aggregates into different ratios in serum, we achieved high diagnostic accuracies of 92% for early AD and 95% for late AD ((p-tau-AT8 + ASC)/Aβ ratio) and of up to 98% for PD (both α-syn + ASC)/Aβ and ASC/Aβ.