IL1B and Parkinson disease: We found that the serum levels of IL-1β positively correlated with ASC speck levels HCs (R = 0.54, p = 0.088) (See the Supplementary Fig. 8A, D) and in PD and HC samples combined (R = 0.43, p = 0.075) but not in the PD serum samples alone (R = −0.3, p = 0.52), likely due to the small sample size (n = 7 PD cases).