We took the proportion of morphologically distinctive serum ASC specks established above and added them to a panel of the number of ASC specks, α-syn aggregates and Aβ aggregates in PD serum and ASC specks, p-tau-AT8 aggregates and Aβ aggregates in AD serum to explore their different combinations using an unbiased approach (see the data analysis and statistical testing section for details). Here, MAPT is linked to Alzheimer disease.