Serum ASC speck levels showed a better dynamic range (~2-4 fold increase in AD and PD serum compared to controls) than IL-1β 34,35 (1.3-1.4 fold increase in AD and PD serum), and greater sensitivity to differentiate PD/AD from control serum (ASC speck: AUC = 89% AD vs HC serum, AUC = 87% PD vs HC serum compared to IL-1β: AUC = 66% AD from HC serum, AUC = 73% PD from HC serum). Here, IL1B is linked to Alzheimer disease.