Aims of the present study were to elucidate the role of Wee1 in promoting tumour progression in ACC, to test the anti‐tumour effects of Wee1 inhibition, and to investigate the role played by FLNA in regulating Wee1 expression and the response to its specific inhibitor AZD1775 in human ACC cell lines and in patient‐derived primary cultured ACC cells. This evidence concerns the gene WEE1 and neoplasm.