Since alterations in cell cycle‐related genes have been reported as highly important ACC drivers, expression patterns of G2/M phase regulators as CDK1, cyclin B1, polo‐like kinase 1 (PLK1), Cdc25C, and DNA Topoisomerase 2 Alpha (TOP2A), have been extensively studied and found upregulated in ACC compared to ACA and NAG.6, 35, 36, 37, 38, 39. This evidence concerns the gene PLK1 and adrenal cortex carcinoma.