Since alterations in cell cycle‐related genes have been reported as highly important ACC drivers, expression patterns of G2/M phase regulators as CDK1, cyclin B1, polo‐like kinase 1 (PLK1), Cdc25C, and DNA Topoisomerase 2 Alpha (TOP2A), have been extensively studied and found upregulated in ACC compared to ACA and NAG.6, 35, 36, 37, 38, 39. The gene discussed is CDC25C; the disease is adrenal cortex carcinoma.