MAPT and synucleinopathy: Next, coexistence and colocalization of α-synwith Aβ and tau aggregates require a PET tracer with high selectivityover Aβ and tau to be able to image α-syn.5 Knowledge of the structures of α-syn filaments andhow they form may be used for the development of specific biomarkersfor synucleinopathies and the development of safe and effective mechanism-basedtherapies.