SOCS3 and neoplasm: The suppressor of cytokine signaling 1 (SOCS1) and suppressor of cytokine signaling 3 (SOCS3), downstream effectors of AXL signaling, play crucial roles in modulating tumor immune responses and immunotherapy sensitivity.[40] AXL KD decreased SOCS1 and SOCS3 in KIRC cells (Figure S13A,B, Supporting Information).