Multiple mechanisms exist through which RCC evades the immune system and immune checkpoint signaling represents a crucial subsection among them.[2b] Our results showed that STAMBPL1 led to an increase in mRNA and protein level of PD‐L1 in KIRC cells mainly through promoting RELA/p65 nuclear translocation and NF‐kappa B signaling activation, as nuclear p65 could directly bind to PD‐L1 promoter to stimulate its transcription. This evidence concerns the gene CD274 and renal cell carcinoma.