Consistently, the inhibitory effect of STAMBPL1 KD on tumor metastasis was also confirmed in NOD‐SCID mice using an orthotopic xenograft tumor model, in which AXL expression or TRIM21 KD reversed the effect (Figure 5J,K), meanwhile, the orthotopic tumor mass within the respective groups did not exhibit apparent differences (Figure 5L). Here, TRIM21 is linked to neoplasm.