Previous studies reported that AXL activated AKT pathway to enhance MYC protein accumulation while MYC could reciprocally upregulate AXL expression in breast cancer cells, suggesting a potential interaction between MYC and the STAMBPL1/TRIM21/AXL axis through the AKT signaling pathway in renal cancer.[68] Andrea et al. The gene discussed is STAMBPL1; the disease is breast cancer.