Thus, here we developed a substantially less intensive, streamlined method to induce PTLD-like disease in SIV+ MCMs using a combination of antibody-mediated CD8α+ cell depletion and infusion of autologous CyLCV-BLCL, paired with up to four additional immunosuppressants commonly employed in transplantation. Here, CD8A is linked to post-transplant lymphoproliferative disease.