We hypothesized that infusion of autologous CyLCV-BLCLs into simian immunodeficiency virus (SIV)-infected, CD8α+ cell-depleted MCMs would predispose macaques to PTLD-like disease, particularly with additional immunosuppression impacting T cells known to be critical for maintaining EBV control. Here, CD8A is linked to post-transplant lymphoproliferative disease.