The results showed that OA or inosine alone hardly affected cLPS-induced systemic inflammation (Figure 4—figure supplement 5A–C) and MSU crystal-induced peritonitis (Figure 4—figure supplement 5D–H), as well as plasma sUA levels and whole blood NAD+ metabolism under inflammatory conditions (Figure 3—figure supplement 4E–H). The gene discussed is CLPS; the disease is peritonitis.