Functional evidence strongly supports a causal role for ADAMTS7 in CAD [44], and in the arterial tissues where the GWAS SNPs in this locus were associated with ADAMTS7 expression, our method correctly predicted ADAMTS7 as the causal gene, and not CTSH, another gene in this locus with cis-eQTL associations in the same tissues. Here, CTSH is linked to coronary artery disorder.