Meanwhile, the upregulated mRNA levels of FN, CTGF, Col1a1 and Col3a1 in the TAC + rAAV9‐miR + SRI group further indicated that SRI‐011381 administration significantly reversed the inhibitory effect of rAAV9‐POSTN‐miR‐425‐5p on myocardial fibrosis (Figure 8D–G). This evidence concerns the gene COL1A1 and Myocardial fibrosis.