The expression levels of these three miRNAs were elevated by WT p53 but not by mutant p53 (Figure 8F); meanwhile, miR‐34a and miR‐499a/b inhibited cell invasion (Figure S6E, Supporting Information), cell proliferation (Figure S6F, Supporting Information), and lactate production (Figure S6G, Supporting Information) in Ishikawa cells with GAL9 overexpression, highlighting the negative regulation of p53/three‐miRNAs on MGAT4A expression for glucose metabolism and tumor aggressiveness. This evidence concerns the gene MGAT4A and neoplasm.