LGALS9 and neoplasm: As a versatile secretory protein, GAL9 might affect not only tumor cells but also various components of the tumor stroma, including TIM‐3‐mediated T cell death, M2 polarization of macrophage, and expansion of myeloid‐derived suppressor cells.[55, 56, 57] On the other hand, dysregulated glycotransferases in tumor cells may also regulate N‐glycosylation of the membrane proteins to reduce tumor surveillance.