The NLRP3 inflammasome has been proposed to exert dual functions in age‐related macular degeneration (AMD), with activation associated with both drusen in dry AMD‐like injury and the prevention of neovascularization in wet AMD.[22] Lukens, Udden, and our group also reported that the newly identified inflammasome NLRP12 acts as a critical mediator of autoinflammatory disease, tumor progression, and pathogen infection.[23, 24, 25] However, neither its involvement in pyroptosis nor regulation by AIP1 has been examined. The gene discussed is NLRP12; the disease is wet macular degeneration.