Pathologic retinal angiogenesis is a chronic and progressive process, typically initiated by ischemia or hypoxia due to vessel loss, which subsequently enhances the production of pro‐angiogenic vascular endothelial growth factor (VEGF), leading to excessive vessel formation that interferes with retinal light detection.[1] The precise mechanisms by which retinal ischemia or hypoxia induces neovascularization are poorly understood. This evidence concerns the gene VEGFA and ischemia.