AFP and hepatocellular carcinoma: Multiphase CT has been shown to have a higher sensitivity (73.6% vs. 59.3%) and positive predictive value (PPV; 85.8% vs. 77.4%) than US alone in a recent meta-analysis, again noting that the sensitivity is near equivalent when US is used in combination with serum AFP for early-stage HCC, as is recommended in the current national guidelines [14, 17] (Fig. 4).