SREBF1 and Parkinson disease: Other lipid-related genes associated with an increased risk of PD include DGKQ (encoding diacylglycerol kinase theta)(19,20), which is crucial for the formation of synaptic vesicles by mediating the regeneration of phosphatidylinositol from diacylglycerol(21,22), and SREBF1, which encodes sterol regulatory element binding transcription factor 1(23), essential for biosynthesis and cell membrane integrity(24).