SIRT1 and diabetes mellitus: Treadmill training has also been found to reverse the downregulation of cystathionine β-synthase and cystathionine γ-lyase, thereby enhancing endogenous hydrogen sulfide production in the kidney, inhibiting the SIRT1/p53 apoptosis pathway, and alleviating diabetes-associated renal injury in streptozotocin-induced diabetic mice (120).