Cannabidiol (CBD) has been suggested for the treatment of HCC by inhibiting aerobic glycolysis, which induces mitochondrial stress by regulating the ATF4–IGFBP1–Akt axis, to activate caspase-3, initiating the GSDME-mediated pyroptosis pathway [34] (Figure 2). This evidence concerns the gene GSDME and hepatocellular carcinoma.