The N-terminal binds to lipids on the cellular membrane and oligomerizes to form Gasdermin (GSDM) pores, which destroys the integrity of the cellular membrane, triggers the release of pro-inflammatory cytokines, such as interleukin 1beta (IL-1β) and interleukin 18 (IL-18), causing pyroptosis, and promotes the death of tumor cells [12, 13] (Figure 1). Here, IL18 is linked to neoplasm.