On the other hand, unusually low concentrations of NO in the organism are a strong indicator for endothelium dysregulation and damage, for predisposition to severe cardiovascular disease, and other cardiovascular complications, if these are not already pathologically prevailing.108 During oxidative stress, low levels of NO predict that most of the NO synthesized by either eNOS or nNOS, or by inducible NOS (iNOS) (a special NOS induced under immune stimulation), is converted to peroxynitrite. This evidence concerns the gene NOS2 and cardiovascular disorder.