Cognitive impairment-associated neuro-oxidative stress inflammation parallels increased cytokine profile including IFN-α, TGF-β, TNF-β, IL-6, IL-7, IL-13, IL-15 and G-CSF. Cognitive impairment is significantly associated with CRP and D-dimer levels.16,89. The gene discussed is TGFB1; the disease is Cognitive impairment.