Hypertension, glycosuria and hyperglycaemia-i nduced upregulation of NHE-3 in the renal proximal tubules all contribute to glomerular hyperfiltration.135 DPP-4 inhibitors are assumed to modulate the contributing mechanisms involved in glomerular hyperfiltration in a GLP-1R-dependent manner. The gene discussed is SLC9A3; the disease is hypertensive disorder.