DPP4 and systemic sclerosis: Fibroblasts exhibiting increased myofibroblast markers are isolated from patients with systemic sclerosis and have extensive DPP-4 expression.86 In addition, DPP-4-expressing fibroblasts were found to constitute the majority of connective tissues, which were deposited in the skin after surgical wounding.90 Consistently, DPP-4 inhibitors decreased scarring without adversely affecting wound healing, highlighting the selective expression pattern of DPP-4 in fibroblast population with a high capability of ECM production, rather than those with more homeostatic functions.90