Hypertension, glycosuria and hyperglycaemia-i nduced upregulation of NHE-3 in the renal proximal tubules all contribute to glomerular hyperfiltration.135 DPP-4 inhibitors are assumed to modulate the contributing mechanisms involved in glomerular hyperfiltration in a GLP-1R-dependent manner. Here, GLP1R is linked to Hyperglycemia.