IL10 and major depressive disorder: In the insula, no difference was detected for the anti-inflammatory cytokines (IL-4: F1,37 = 1.656, p = 0.206, IL-10: F1,37 = 2.409, p = 0.129 and IL-13: F1, 37 = 0.551, p = 0.462, Fig. 2C–E), indicating that depression does not impact the anti-inflammatory cytokine expression in this area.